In particular, the simple amino acid glycine is emerging as a key endogenous regulator of inflammation, via direct action on the plasma membranes of macrophages and other effector cells. These glycine receptors are actually glycine-gated chloride channels, by which glycine allows for chloride influx, stabilizing membrane resting potential, and thus raising the threshold for activation to produce an impressive array of poisons necessary to repel a microbial infection. The resulting inflammatory response, when exaggerated and chronic, seems to lie at the root of the chronic diseases under consideration here. READ it HERE
Glycine & Autism Spectrum Disorder
Letter published at British Medical Journal (BMJ) blog by Dr. Joel Brind, responding to the clinical review published in the British Medical Journal (BMJ2018) titled:
Autism spectrum disorder: advances in diagnosis and evaluation
BMJ 2018; 361 doi: https://www.bmj.com/content/361/bmj.k1674/rr-3 (Published 21 May 2018) READ HERE
Inflammation & Heart Disease
Drew Mariani of Relevant Radio interviewed Dr. Joel Brind to discuss the results of a research study showing the role of inflammation in heart disease. May 24, 2018. Listen to their informative discussion Listen HERE.
(video) Part 2 Anti-inflammatory properties of Glycine
Part 2 consists of Dr. Joel Brind talking about glycine, the body’s most abundant non-essential amino acid and how it works to regulate your body’s inflammation, potentially preventing harmful diseases.
(video) Part 3 Anti-inflamatory properties of Glycine
Part 3 of Dr. Joel Brind’s interview about glycine, its unique characteristics and how it fights your body’s inflammation
Rheumatoid Arthritis & Glycine
Letter published in British Medical Journal (BMJ) blog, by Dr. Joel Brind, responding to the clinical review titled:
Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications
BMJ 2018; 361 doi: https://doi.org/10.1136/bmj.k1036 (Published 23 April 2018)Cite this as: BMJ 2018;361:k1036 READ it: https://www.bmj.com/content/361/bmj.k1036/rr-0
In compiling their extensive review England et al.(1) cast a rather narrow net, using only “the MeSH terms ‘rheumatoid arthritis’ and ‘cardiovascular disease’ or ‘cardiovascular system’”. Considering the common denominator that emerged as a major focus, namely, “shared inflammatory mediators”, and the fact that so many other widespread and devastating diseases such as diabetes and cancer are linked to inflammation, it would seem that looking upstream for causes of inflammation rather than downstream toward specific sequelae and treatment regimens for RA and CVD might be more fruitful in identifying common threads and hopefully, better prevention and treatment strategies.
Recent Findings Linking Inflammation to Disease Development
Drew Mariani of Relevant Radio interviewed Dr. Joel Brind on recent research findings connecting inflammation to disease development. Learn about how glycine works to regulate inflammation at the cellular level, March 1, 2018. Listen to their interview in these two-part podcast. Listen to part 1
Listen to part 2
Cancer Risk & Glycine
Letter published at the British Medical Journal (BMJ) by Dr. Joel Brind responding to research article on factors influencing cancer risk.
Cancer risk associated with chronic diseases and disease markers: prospective cohort study
BMJ 2018; 360 doi: https://doi.org/10.1136/bmj.k134 (Published 31 January 2018)Cite this as: BMJ 2018;360:k134
READ it: https://www.bmj.com/content/360/bmj.k134/rr-1
This study by Tu et al.(1) adds materially to the quest for a common denominator in the etiology of the major chronic diseases of the modern industrialized world. I believe their “overlooked link” between chronic disease and markers and risk of cancer” as well as “a substantial reduction in lifespan” may be extended further in the context of other recent research on multiple fronts. Specifically, inflammation has emerged in recent years as a common factor in cancer, cardiovascular disease and diabetes, as well as arthritis and other frank inflammatory diseases. While many investigators have been searching for particular dietary and environmental triggers of inflammation, and pharmaceutical investigative efforts have focused on targeting specific populations of myeloid effector cells (macrophages), a single molecular entity may be emerging as an “overlooked link”in this regard: The simplest amino acid, glycine. READ MORE HERE
Jacki Daily Show
I was just interviewed on the Blaze radio network, specifically, on the Jacki Daily Show on Sunday, June 4. The show is generally about energy issues; including oil and petrochemicals. So this interview took the approach of how so many ailments are blamed on petrochemicals in some way, but the answer is really more about inflammation and glycine deficiency. Here's the link to the podcast:
(Video) Dr. Joel Brind about the role of glycine in regulating inflammation
Watch and listen as Dr. Brind teaches his biology class about the natural purpose of inflammation and the role of glycine in regulating it. See how supplementing the diet with glycine, inflammation does not happen unless there is an infection.
Glycine enriched diet allows for your body to properly fight inflammation.
Pain Free Shingles and Other Glycine Benefits
Learn how feeding your body enough glycine can eliminate excess inflammation that causes the pain in shingles, gout, reflex sympathetic dystrophy and many other conditions
180degreehealth posts on Glycine
Matt Stone - 180degreehealth.com
Matt Stone - 180degreehealth.com
Glycine & inflammation, cancer and glutathione
Although they haven’t been posted on this NFS blog site, Dr. Brind has been busy writing up a storm about nutrition and health, and posted 6 articles since the summer on Matt Stone’s 180degreehealth.com. You’ll note that in addition to the articles themselves, there is a very lively dialog following each of those posts with the well-informed readership of 180degreehealth, so many health and nutritional questions that have come up in real peoples’ lives are discussed and answered in depth.
So enjoy the articles and feel free to jump right in on the discussions!
NIH to test glycine supplementation in mice!
Glycine supplementation in mice. Followers of this blog are no strangers to the idea of glycine supplementation—as with sweetamine—to eliminate excess inflammation. And there is also plenty of peer-reviewed research to back up glycine’s anti-inflammatory role. Then again, even if most of the conditions that make people sick and die these days—heart disease, cancer, etc—are now know to be tied to chronic inflammation, no claims as to glycine’s ability to prevent such diseases can yet be made, because this must be proven through peer-reviewed published studies on lab animals over years and on real people over decades of time. Toward that end, the National Institute on Aging—one of the National Institutes of Health (NIH)—has just decided to give us a good start by setting up a multi-center study on glycine supplementation in mice, using a protocol designed by yours truly.
Last September, I submitted an application to the NIA’s Interventional Testing Program (ITP). It is like submitting a grant application to the NIH, except that the Sponsor (myself, in this case) does not involve his own institution in the research directly: The entire study is performed at 3 study centers: at the University of Michigan, the University of Texas, and the Jackson Labs in Maine, by NIA-funded scientists, according to the protocol proposed by the sponsor. Every year, the NIA selects up to 5 dietary interventions that are hypothesized to extend the lifespan of the mice and/or delay the onset of age-related diseases. The Sponsor, however, has access to all the data generated, participates in the analysis of the data and is a co-author on resulting published studies.
Of course, the NIA’s decision to run the glycine supplementation experiment does not mean there will results overnight. Even intermediate results on the delay of age/inflammation-related conditions are likely at least two years away, but it’s a great start!
Sweetamine/Proglyta take silver and gold at NJ Senior Olympics
Last month, at the annual New Jersey Senior Olympic Games in Woodbridge, NJ, Proglyta/sweetamine customer Lester Darmstadt of Long Beach, NY, took the silver medal in the men’s 65-69-year-old 200-meter dash, and the gold in the 100-meter dash.
The annual state Senior Games are run by the National Senior Games Association, which holds its nation-wide competition every other year on odd years. I started feeling so good myself on daily Proglyta (now daily sweetamine), that I signed up and started running the 200-meter dash last year in the NY and NJ games. (That was my event the last time I ran track in school; Junior high school that is, literally a half century ago!) I didn’t really keep in training, but I did complete the races last year and at this year’s NJ event on September 7. (For those of you who know about track and field, I ran the 200-meter dash in 37.45 seconds; respectable for my age, but nothing to blog about.) READ it HERE
Is Shark cartilage anti-inflammatory and anti-cancer?
Shark cartilage is one of the staples among nutraceuticals, on the shelves of health food stores for quite a few years now. It is touted for its anti-inflammatory benefits in treating arthritis and other inflammatory conditions and especially, cancer.
The use of powdered cartilage to treat wounds was originally popularized by John Prudden, a surgeon from New York, in 1954. Prudden used powdered cartilage from cows, finding it effective in the acceleration of wound healing, the treatment of arthritis, inflammatory bowel disease and even advanced cancer.
Cartilage from sharks was popularized by the 1992 bestseller by William Lane and Linda Comac: “Sharks don’t get cancer”, followed by “Sharks still don’t get cancer” in 1996. The point of the claim was to imply that there is something unique about cartilage from an animal—like a shark—whose skeleton is entirely made of cartilage—not bone, and that there are curative powers which can only come from that type of animal. Of course, convincing millions of people that only shark cartilage will do is not particularly healthy for shark populations around the world, and shark populations have indeed suffered, as the commercial market for shark cartilage has skyrocketed. READ it HERE
To love or hate the sun: That is the perennial summer question
Summer’s here again, and these days, health-conscious Americans wonder whether to go with the traditional slathering on of sunscreens and sunblocks to avoid sunburn and skin cancer, or to back off those butterings at least enough to avoid the consequences of Vitamin D deficiency.
The following scenario is likely familiar to you—If you have light skin and are prone to sunburn, that is: You spend maybe an hour or two in the sun. Then, feeling extra warmth on your skin coming from the inside, you look down and notice that all your exposed parts are bright red (the “boiled lobster” look). Then you get that sinking feeling of having totally forgotten about the sunscreen and knowing that, even though you get in the shade immediately and stay there, in a matter of hours it will be horribly painful even to get dressed or undressed or bathe. After a couple of days, when the pain subsides, that reddened skin will have turned into an ugly, peeling mess. Finally, a week later, you’ll be pretty much back to where you started with that pale and vulnerable skin, newly resolved never to forget the sunscreen again! Read it HERE
Turn Any Diet into an Anti-Inflammatory Diet!
Scientists, doctors and the general public are finally catching on to the fact that most diseases that make people sick and die these days—including heart disease and cancer—can be traced to a condition of chronic inflammation (See my earlier post: “What is inflammation?“) They are also catching on to the fact that chronic inflammation can be limited or even eliminated by eating an anti-inflammatory diet. And you don’t have to look very far online for plenty of suggestions for what to eat in an anti-inflammatory diet, most of which are pretty similar, and—for most people—hard to follow without a complete dietary makeover. That’s because most anti-inflammatory diets start with a long list of stuff you should not eat.